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KMID : 0362320070320060514
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Journal of Korean Academy of Operative Dentistry
2007 Volume.32 No. 6 p.514 ~ p.521
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EXPRESSION OF P2X_3 AND ITS COLOCALIZATION WITH TRPV1 IN THE HUMAN DENTAL PULP
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Kim Young-Kyung
Kim Sung-Kyo
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Abstract
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The purinoreceptor, P2X_3 is a ligand-gated cation channel activated by extracellular ATP. It has been reported that ATP can be released during inflammation and tissue damage, which in turn may activate P2X_3 receptors to initiate nociceptive signals. However, little is known about the contribution of P2X_3 to the dental pain during pulpal inflammation. Therefore, the purpose of this study was to investigate the expression of P2X_3 and its colocalization with TRPV1 to understand the mechanism of pain transmission through P2X_3 in the human dental pulp with double labeling immunofluorescence method.
In the human dental pulp, intense P2X_3 immunoreactiyity was observed throughout the coronal and radicular pulp. Of all P2X_3-positive fibers examined, 79.4% coexpressed TRPV1.
This result suggests that P2X_3 along with TRPV1 may be involved in the transmission of pain and potentiation of noxious stimuli during pulpal inflammation.
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KEYWORD
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P2X_3 receptor, Immunofluorescence method, Human dental pulp, TRPV1, Transmission of pain
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